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CS-W001157 4
Total: USD 88.00

2-Chloro-4-methylquinoline

  • CAS No. 634-47-9

  • Cat. No. CS-W017357
  • Purity≥95%
  • MDL No.MFCD00006742

*For research and further manufacturing use only, not for direct human use.

2-Chloro-4-methylquinoline|CS-W017357

Structure of 634-47-9

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General Information

  • CAS No. 634-47-9
  • Cat. No. CS-W017357
  • Purity ≥95%
  • MDL No. MFCD00006742
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₈ClN
  • Molecular Weight None
  • Synonym(s) 2-chlorolepidine
  • SMILES CC1=CC(Cl)=NC2=C1C=CC=C2

Description

2-Chloro-4-methylquinoline is a heterocyclic compound featuring a quinoline core with strategically positioned chlorine and methyl substituents. This combination imparts enhanced electron-deficient character at the ring system, facilitating efficient coupling reactions in transition metal-catalyzed processes. The molecule exhibits excellent stability under standard bench conditions and demonstrates favorable solubility in common organic solvents, enabling seamless integration into synthetic workflows for pharmaceutical intermediates and functional materials.

Application

2-Chloro-4-methylquinoline serves as a versatile building block in medicinal chemistry, enabling efficient construction of quinoline-based scaffolds. The chloro group at C2 facilitates palladium-catalyzed cross-coupling reactions, while the methyl substituent at C4 enhances solubility and modulates electronic properties. Its bench-stable nature and compatibility with diverse functional groups make it ideal for iterative synthesis workflows in API development.

Synthesis

  • Route1

    References

    • Chemische Berichte, , vol. 42, p. 3337
  • Route2
    • In-stock
      2-Hydroxy-4-methylquinoline|CS-0159934
      607-66-9
    • null|null
      10026-13-8
    • ~%
    • In-stock
      2-Chloro-4-methylquinoline|CS-W017357
      634-47-9

    References

    • Justus Liebigs Annalen der Chemie, , vol. 236, p. 105
  • Route3

    References

    • Kato, Taka-Aki; Hakura, Atsushi; Mizutani, Takaharu; Saeki, Ken-Ichi Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2000 , vol. 465, # 1-2 p. 173 - 182

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.19662
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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