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CS-W001157 4
Total: USD 88.00

2,5-Dihydro-1H-pyrrole hydrochloride

  • CAS No. 63468-63-3

  • Cat. No. CS-W016634
  • Purity≥97%
  • MDL No.MFCD09991892

*For research and further manufacturing use only, not for direct human use.

2,5-Dihydro-1H-pyrrole hydrochloride|CS-W016634

Structure of 63468-63-3

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General Information

  • CAS No. 63468-63-3
  • Cat. No. CS-W016634
  • Purity ≥97%
  • MDL No. MFCD09991892
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₈ClN
  • Molecular Weight 105.57
  • Synonym(s) 1H-Pyrrole, 2,5-dihydro-, hydrochloride
  • SMILES [H]Cl.N1CC=CC1

Description

2,5-Dihydro-1H-pyrrole hydrochloride offers a stable, moisture-tolerant platform for heterocyclic synthesis. This bench-stable salt features a reactive pyrroline core that integrates readily into complex molecular architectures. Its defined protonation state enhances solubility in polar media and simplifies handling during multistep transformations.

Application

2,5-Dihydro-1H-pyrrole hydrochloride serves as a stable, bench-ready building block for heterocyclic synthesis. Its well-defined nitrogen functionality enables straightforward incorporation into diverse scaffolds, particularly in the construction of pyrrolidine-based intermediates and bioactive molecules. The hydrochloride salt enhances solubility and handling, facilitating use in standard coupling and functionalization reactions.

Synthesis

  • Route1
    • null|null
      109-97-7
    • ~79%
    • In-stock
      2,5-Dihydro-1H-pyrrole hydrochloride|CS-W016634
      63468-63-3

    References

    • Burdi, Douglas F.; Hunt, Rachel; Fan, Lei; Hu, Tao; Wang, Jun; Guo, Zihong; Huang, Zhiqiang; Wu, Chengde; Hardy, Larry; Detheux, Michel; Orsini, Michael A.; Quinton, Maria S.; Lew, Robert; Spear, Kerry Journal of Medicinal Chemistry, 2010 , vol. 53, # 19 p. 7107 - 7118
  • Route2
    • Diallylamine hydrochloride|CS-W011074
      6147-66-6
    • ~67%
    • In-stock
      2,5-Dihydro-1H-pyrrole hydrochloride|CS-W016634
      63468-63-3

    References

    • Connon, Stephen J; Blechert, Siegfried Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 14 p. 1873 - 1876
  • Route3
    • null|null
      77484-76-5
    • ~98%
    • In-stock
      2,5-Dihydro-1H-pyrrole hydrochloride|CS-W016634
      63468-63-3

    References

    • Gajda, Tadeusz; Zwierzak, Andrzej Liebigs Annalen der Chemie, 1986 , # 6 p. 992 - 1002

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   0.5676
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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