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Structure of 63555-50-0
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Methyl 3-(chlorosulfonyl)benzoate is a bench-stable, moisture-tolerant reagent featuring a chlorosulfonyl group ortho to the ester moiety. This configuration enables direct sulfonation of aromatic systems under mild conditions. The compound integrates readily into synthetic sequences requiring electrophilic sulfur transfer, offering a reliable route to sulfonyl-containing heterocycles and functionalized arylsulfonates.
Methyl 3-(chlorosulfonyl)benzoate serves as a versatile synthetic intermediate for introducing sulfonate functionality at the meta-position of aromatic rings. The chlorosulfonyl group enables direct nucleophilic substitution with amines, alcohols, and thiols under mild conditions, facilitating the construction of sulfonamide, sulfonate ester, and thioether derivatives. Its bench-stable nature and compatibility with common protecting groups make it ideal for multi-step synthesis in medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H314
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501
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Lot numbers can be found on the outside label of a product: