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CS-W001157 4
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2-Methyl-1H-pyrrole

  • CAS No. 636-41-9

  • Cat. No. CS-W011360
  • Molecule weight81.12
  • Purity≥98%
  • MDL No.MFCD02822910

*For research and further manufacturing use only, not for direct human use.

2-Methyl-1H-pyrrole|CS-W011360

Structure of 636-41-9

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General Information

  • CAS No. 636-41-9
  • Cat. No. CS-W011360
  • Purity ≥98%
  • MDL No. MFCD02822910
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇N
  • Molecular Weight 81.12
  • Synonym(s) Pyrrole, 2-methyl- (8CI)
  • SMILES CC1=CC=CN1

Description

2-Methyl-1H-pyrrole is a bench-stable, electron-rich heterocycle featuring a methyl group at the 2-position, enhancing its reactivity in electrophilic substitution. This substituted pyrrole serves as a key scaffold in synthetic organic chemistry and pharmaceutical intermediates, offering improved solubility and compatibility in diverse reaction conditions.

Application

2-Methyl-1H-pyrrole serves as a versatile heterocyclic building block in synthetic organic chemistry, enabling efficient access to substituted pyrroles via electrophilic substitution and transition-metal-catalyzed coupling reactions. Its methyl group enhances regioselectivity in functionalization, while the inherent stability and solubility facilitate straightforward purification and integration into complex molecular architectures.

Synthesis

  • Route1

    References

    • Murat-Onana, Marie Laure; Berini, Christophe; Minassian, Frederic; Pelloux-Leon, Nadia; Denis, Jean-Noel Organic and Biomolecular Chemistry, 2010 , vol. 8, # 9 p. 2204 - 2211
  • Route2

    References

    • Lash, Timothy D.; Richter, Daniel T.; Shiner, Craig M. Journal of Organic Chemistry, 1999 , vol. 64, # 21 p. 7973 - 7982
  • Route3
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    • In-stock
      2-Methyl-1H-pyrrole|CS-W011360
      636-41-9

    References

    • Journal of the American Chemical Society, , vol. 58, p. 709,713,715

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS06
Signal Word : Danger
UN#: 1992
Class : 3,6.1
Packing Group : Ⅲ
Hazard Statements : H225-H301-H315-H319-H332-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501

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Computational Chemistry Data

  • TPSA   15.79
  • LogP   1.32312
  • H_Acceptors   0
  • H_Donors   1
  • Rotatable_Bonds   0

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