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CS-W001157 4
Total: USD 88.00

5-Chloropyrimidine-4-carboxylic acid

  • CAS No. 64224-65-3

  • Cat. No. CS-0084583
  • Molecule weight158.54
  • Purity≥98%
  • MDL No.MFCD09754103

*For research and further manufacturing use only, not for direct human use.

5-Chloropyrimidine-4-carboxylic acid|CS-0084583

Structure of 64224-65-3

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General Information

  • CAS No. 64224-65-3
  • Cat. No. CS-0084583
  • Purity ≥98%
  • MDL No. MFCD09754103
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClN₂O₂
  • Molecular Weight 158.54
  • Synonym(s) None
  • SMILES O=C(C1=NC=NC=C1Cl)O

Description

5-Chloropyrimidine-4-carboxylic acid features a chlorine-substituted pyrimidine core paired with a carboxylic acid group, enabling direct incorporation into bioactive scaffolds. The electron-deficient ring system facilitates nucleophilic substitution reactions, while the acidic functionality supports salt formation and conjugation. This compound serves as a key intermediate in medicinal chemistry for constructing heterocyclic frameworks with enhanced metabolic stability and target affinity.

Application

5-Chloropyrimidine-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C4 position via nucleophilic substitution or coupling reactions. Its bench-stable nature and tolerance to common protecting groups facilitate integration into complex heterocyclic scaffolds. The carboxylic acid moiety supports derivatization for prodrug strategies or conjugation, while the chloro group provides a reliable handle for late-stage modification in API development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   63.08
  • LogP   0.8282
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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