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Structure of 64241-77-6
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3-Fluoro-2,2-dimethylpropanoic acid features a sterically hindered quaternary carbon center flanked by a fluorine atom and two methyl groups, delivering enhanced metabolic stability. This electron-withdrawing fluorinated scaffold integrates readily into bioactive molecules, offering improved membrane permeability and resistance to enzymatic degradation in medicinal chemistry applications.
3-Fluoro-2,2-dimethylpropanoic acid serves as a valuable building block in medicinal chemistry, offering a sterically hindered, fluorinated aliphatic carboxylic acid scaffold. Its stability and resistance to β-elimination facilitate reliable coupling reactions, enabling efficient incorporation into peptide and non-peptidic molecular architectures. The trifluoromethyl-like electronic profile, combined with enhanced metabolic stability, makes it particularly useful for optimizing pharmacokinetic properties in drug candidates.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H302-H314
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Precautionary Statements : P260-P264-P270-P280-P304+P340-P331-P363-P405-P501
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Lot numbers can be found on the outside label of a product: