2,5-Difluorobenzonitrile

Name: 2,5-Difluorobenzonitrile
Brand: ChemScene
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CAS No. 64248-64-2
Cat. No. CS-W016483
Purity≥97%
MDL No.MFCD00001777

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 64248-64-2

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Description

2,5-Difluorobenzonitrile features a fluorinated aromatic core with nitrile functionality, offering enhanced electronic withdrawal and metabolic stability. This bench-stable compound integrates readily into pharmaceutical intermediates and agrochemical scaffolds, where electron-deficient aryl groups enable selective coupling reactions under mild conditions.

Application

2,5-Difluorobenzonitrile serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct introduction of fluorinated aryl motifs with orthogonal functional handles. The nitrile group facilitates downstream transformations including amidation, reduction to primary amine, or cyclization into heterocycles. Its bench-stable nature and compatibility with palladium-catalyzed cross-coupling reactions support efficient late-stage functionalization in complex molecule assembly.

General Information

CAS No. 64248-64-2
Cat. No. CS-W016483
Purity ≥97%
MDL No. MFCD00001777
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₃F₂N
Molecular Weight 139.11
Synonym(s) 2,5-difluoro nitrile
SMILES FC1=CC(C#N)=C(F)C=C1

Computational Chemistry Data

TPSA 23.79
LogP 1.83648
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Cyanide/Nitrile

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2,5-Difluorobenzonitrile

CAS No. 64248-64-2

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