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CS-W001157 4
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2-(1-(Tert-butoxycarbonyl)-4-phenylpiperidin-4-yl)acetic acid

  • CAS No. 644982-20-7

  • Cat. No. CS-0454652
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(1-(Tert-butoxycarbonyl)-4-phenylpiperidin-4-yl)acetic acid|CS-0454652

Structure of 644982-20-7

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General Information

  • CAS No. 644982-20-7
  • Cat. No. CS-0454652
  • Purity ≥98%
  • MDL No. None
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₈H₂₅NO₄
  • Molecular Weight 319.40
  • Synonym(s) 4-CARBOXYMETHYL-4-PHENYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • SMILES CC(C)(C)OC(=O)N1CCC(CC1)(CC(=O)O)C2=CC=CC=C2

Synthesis

  • Route1

    References

    • GLAXO GROUP LIMITED Patent: WO2004/5256 A2, 2004 ; Location in patent: Page 47-48 ; WO 2004/005256 A2
  • Route2
    • Tert-butyl 4-cyano-4-phenylpiperidine-1-carboxylate|CS-0272817
      158144-79-7
    • ~%
    • 2-(1-(Tert-butoxycarbonyl)-4-phenylpiperidin-4-yl)acetic acid|CS-0454652
      644982-20-7

    References

    • Kazmierski, Wieslaw M.; Anderson, Don L.; Aquino, Christopher; Chauder, Brian A.; Duan, Maosheng; Ferris, Robert; Kenakin, Terrence; Koble, Cecilia S.; Lang, Dan G.; Mcintyre, Maggie S; Peckham, Jennifer; Watson, Christian; Wheelan, Pat; Spaltenstein, Andrew; Wire, Mary B.; Svolto, Angilique; Youngman, Michael Journal of Medicinal Chemistry, 2011 , vol. 54, # 11 p. 3756 - 3767
  • Route3

    References

    • Kazmierski, Wieslaw M.; Anderson, Don L.; Aquino, Christopher; Chauder, Brian A.; Duan, Maosheng; Ferris, Robert; Kenakin, Terrence; Koble, Cecilia S.; Lang, Dan G.; Mcintyre, Maggie S; Peckham, Jennifer; Watson, Christian; Wheelan, Pat; Spaltenstein, Andrew; Wire, Mary B.; Svolto, Angilique; Youngman, Michael Journal of Medicinal Chemistry, 2011 , vol. 54, # 11 p. 3756 - 3767

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   3.43
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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