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Structure of 651-97-8
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3,6-Difluorophthalic acid features a rigid aromatic core with strategically positioned fluorine atoms at the 3 and 6 positions, enhancing electron-withdrawal and metabolic stability. This difunctional scaffold integrates readily into polymers and bioconjugates, offering improved solubility and thermal resilience under standard conditions.
3,6-Difluorophthalic acid serves as a valuable building block in the synthesis of fluorinated aromatic scaffolds and pharmaceutical intermediates. Its ortho-dicarboxylic acid functionality enables efficient amide formation, esterification, and cyclization reactions, while the geminal difluoro substitution enhances metabolic stability and modulates electronic properties. The compound exhibits good bench stability and facilitates purification via recrystallization, making it well-suited for use in iterative synthetic sequences and API development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: