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Structure of 651026-98-1
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3-Bromo-2,4-difluorobenzoic acid features a trifunctional aromatic core with bromine and two fluorine substituents positioned for orthogonal reactivity. This electron-deficient scaffold enables direct coupling in cross-coupling protocols and integrates efficiently into bioactive scaffolds requiring halogen-directed functionalization.
3-Bromo-2,4-difluorobenzoic acid serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling. Its orthogonal reactivity profile—combining a carboxylic acid for derivatization with strategically positioned bromo and difluoro substituents—facilitates diverse scaffold elaboration. The compound exhibits excellent bench stability, straightforward purification, and compatibility with standard coupling conditions, making it well-suited for modular synthesis of bioactive molecules.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P302+P352-P304+P340
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Lot numbers can be found on the outside label of a product: