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CS-W001157 4
Total: USD 88.00

4-Chloro-2-nitropyridine

  • CAS No. 65370-42-5

  • Cat. No. CS-W004881
  • Purity≥98%
  • MDL No.MFCD04114167

*For research and further manufacturing use only, not for direct human use.

4-Chloro-2-nitropyridine|CS-W004881

Structure of 65370-42-5

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General Information

  • CAS No. 65370-42-5
  • Cat. No. CS-W004881
  • Purity ≥98%
  • MDL No. MFCD04114167
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClN₂O₂
  • Molecular Weight 158.54
  • Synonym(s) pyridine, 4-chloro-2-nitro-
  • SMILES O=[N+](C1=NC=CC(Cl)=C1)[O-]

Description

4-Chloro-2-nitropyridine is a bench-stable heterocyclic building block featuring a chloro group at the 4-position and a nitro group at the 2-position of the pyridine ring. This electronic complementarity enables direct functionalization in cross-coupling and nucleophilic substitution reactions, facilitating access to complex nitrogen-containing scaffolds under standard conditions.

Application

4-Chloro-2-nitropyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions and nucleophilic substitution processes. Its orthogonal reactivity allows selective functionalization at the chloro position while preserving the nitro group for subsequent reduction to an amine. The molecule exhibits good bench stability and facilitates efficient synthesis of heterocyclic scaffolds relevant to pharmaceutical development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   56.03
  • LogP   1.6432
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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