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CS-W001157 4
Total: USD 88.00

2-(3-Fluorophenyl)propanoic acid

  • CAS No. 65487-32-3

  • Cat. No. CS-0466093
  • Purity≥97%
  • MDL No.MFCD11036853
  • HazMat Fee +

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    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-(3-Fluorophenyl)propanoic acid|CS-0466093

Structure of 65487-32-3

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Description

This fluorinated phenylpropanoic acid features a para-fluorinated aromatic ring integrated with a chiral aliphatic carboxylic acid moiety. The electron-withdrawing fluorine substituent enhances metabolic stability and modulates lipophilicity, enabling efficient incorporation into bioactive scaffolds. Bench-stable and compatible with standard coupling protocols, this compound serves as a key building block in medicinal chemistry for targeted drug discovery.

Application

2-(3-Fluorophenyl)propanoic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive molecules through standard functional group transformations. Its fluorinated aryl moiety enhances metabolic stability and modulates electronic properties, while the α-methyl carboxylic acid functionality supports efficient derivatization in coupling reactions and heterocycle formation. The compound exhibits good bench stability and is readily purified by recrystallization or chromatography, facilitating integration into scalable synthetic routes.

General Information

  • CAS No. 65487-32-3
  • Cat. No. CS-0466093
  • Purity ≥97%
  • MDL No. MFCD11036853
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉FO₂
  • Molecular Weight 168.16
  • Synonym(s) 3-fluoro-2-methylphenylaceticacid
  • SMILES CC(C1=CC(=CC=C1)F)C(=O)O

Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.0138
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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