2-(3-Fluorophenyl)propanoic acid

Name: 2-(3-Fluorophenyl)propanoic acid
Brand: ChemScene
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CAS No. 65487-32-3
Cat. No. CS-0466093
Purity≥97%
MDL No.MFCD11036853

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-(3-Fluorophenyl)propanoic acid|CS-0466093

Structure of 65487-32-3

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General Information

CAS No. 65487-32-3
Cat. No. CS-0466093
Purity ≥97%
MDL No. MFCD11036853
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₉FO₂
Molecular Weight 168.16
Synonym(s) 3-fluoro-2-methylphenylaceticacid
SMILES CC(C1=CC(=CC=C1)F)C(=O)O

Description

This fluorinated phenylpropanoic acid features a para-fluorinated aromatic ring integrated with a chiral aliphatic carboxylic acid moiety. The electron-withdrawing fluorine substituent enhances metabolic stability and modulates lipophilicity, enabling efficient incorporation into bioactive scaffolds. Bench-stable and compatible with standard coupling protocols, this compound serves as a key building block in medicinal chemistry for targeted drug discovery.

Application

2-(3-Fluorophenyl)propanoic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive molecules through standard functional group transformations. Its fluorinated aryl moiety enhances metabolic stability and modulates electronic properties, while the α-methyl carboxylic acid functionality supports efficient derivatization in coupling reactions and heterocycle formation. The compound exhibits good bench stability and is readily purified by recrystallization or chromatography, facilitating integration into scalable synthetic routes.

Synthesis

Route1
- In-stock
  
  331-25-9
- 74-88-4
- ~%
- In-stock
  
  65487-32-3
References
- AMGEN INC. Patent: WO2009/75874 A1, 2009 ; Location in patent: Page/Page column 100-101 ; WO 2009/075874 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 37.3
LogP 2.0138
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2-(3-Fluorophenyl)propanoic acid

CAS No. 65487-32-3

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