Lot numbers can be found on the outside label of a product:
Methyl 6-chloro-2-methoxynicotinate
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CAS No. 65515-32-4
- Cat. No. CS-W006677
- Purity≥97%
- MDL No.MFCD15142741
*For research and further manufacturing use only, not for direct human use.
Structure of 65515-32-4
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General Information
- CAS No. 65515-32-4
- Cat. No. CS-W006677
- Purity ≥97%
- MDL No. MFCD15142741
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₈ClNO₃
- Molecular Weight 201.61
- Synonym(s) Methyl 6-chloro-2-methoxypyridine-3-carboxylate
- SMILES O=C(OC)C1=C(OC)N=C(Cl)C=C1
Description
Methyl 6-chloro-2-methoxynicotinate is a bench-stable, electron-deficient heterocyclic ester featuring a chlorinated pyridine core. This compound integrates readily into synthetic sequences requiring directed functionalization at the 3-position. The methoxycarbonyl group enables facile derivatization, while the para-chloro substituent serves as a handle for cross-coupling reactions.
Application
Methyl 6-chloro-2-methoxynicotinate serves as a versatile building block in heterocyclic synthesis, enabling efficient access to substituted pyridine scaffolds. The ortho-methoxy and meta-chloro substituents provide complementary reactivity for palladium-catalyzed cross-coupling and nucleophilic substitution reactions. Its bench-stable nature and straightforward purification facilitate integration into multi-step synthetic sequences for pharmaceutical and agrochemical research.
Synthesis
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Route1
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124-41-4 -
In-stock
65515-28-8 - ~94%
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In-stock
65515-32-4
References
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Boos, Charles; Bowles, Daniel M.; Cai, Cuiman; Casimiro-Garcia, Agustin; Chen, Xiangyang; Hulford, Catherine A.; Jennings, Sandra M.; Jason Kiser; Piotrowski, David W.; Sammons, Matthew; Wade, Robert A. Tetrahedron Letters, 2011 , vol. 52, # 52 p. 7025 - 7029
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Route2
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In-stock
58584-86-4 - ~%
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In-stock
65515-32-4
References
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EP2085383 A1, ; Page/Page column 22 ; EP 2085383 A1
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Route3
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In-stock
65515-28-8
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In-stock
65515-32-4
References
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US4089960 A1, ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 48.42
- LogP 1.5302
- H_Acceptors 4
- H_Donors 0
- Rotatable_Bonds 2
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Key Words
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