2-Chloro-6-methoxybenzonitrile

Name: 2-Chloro-6-methoxybenzonitrile
Brand: ChemScene
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CAS No. 6575-10-6
Cat. No. CS-0131325
Purity≥98%
MDL No.MFCD00019743

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-6-methoxybenzonitrile|CS-0131325

Structure of 6575-10-6

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Description

2-Chloro-6-methoxybenzonitrile features a strategically positioned nitrile group flanked by chlorine and methoxy substituents, enabling precise electronic tuning for cross-coupling reactions. This bench-stable, moisture-tolerant aryl building block integrates efficiently into pharmaceutical intermediates and functional materials, offering enhanced reactivity in palladium-catalyzed transformations under standard conditions.

Application

2-Chloro-6-methoxybenzonitrile serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient access to substituted benzimidazoles, quinolines, and other heterocyclic scaffolds via nucleophilic aromatic substitution or palladium-catalyzed coupling. Its ortho-chloro and para-methoxy substituents provide complementary reactivity and electronic modulation, while the nitrile group offers a robust handle for further functionalization. The compound exhibits good bench stability and is readily purified by recrystallization or column chromatography, making it well-suited for high-throughput screening and process development workflows.

General Information

CAS No. 6575-10-6
Cat. No. CS-0131325
Purity ≥98%
MDL No. MFCD00019743
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₆ClNO
Molecular Weight 167.59
Synonym(s) None
SMILES N#CC1=C(OC)C=CC=C1Cl

Computational Chemistry Data

TPSA 33.02
LogP 2.22028
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Cyanide/Nitrile

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2-Chloro-6-methoxybenzonitrile

CAS No. 6575-10-6

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