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CS-W001157 4
Total: USD 88.00

L-Norvaline

  • CAS No. 6600-40-4

  • Cat. No. CS-D1371
  • Purity≥97%
  • MDL No.MFCD00064421

*For research and further manufacturing use only, not for direct human use.

L-Norvaline|CS-D1371

Structure of 6600-40-4

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General Information

  • CAS No. 6600-40-4
  • Cat. No. CS-D1371
  • Purity ≥97%
  • MDL No. MFCD00064421
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₁NO₂
  • Molecular Weight 117.15
  • Synonym(s) Norvaline
  • SMILES N[C@@H](CCC)C(O)=O

Description

Stimulating nitric oxide synthesis in macrophages, L-Norvaline (CAS 6600-40-4) serves as a biosynthetic precursor in penicillin pathways and undergoes acylation with phthalic acid anhydride to form N,N-phthaloyl-L-norvaline.

Application

L-Norvaline (CAS 6600-40-4) interferes with arginine metabolism in tumor-associated macrophages, disrupting metabolic pathways that support tumor immune evasion. This metabolic shift amplifies photodynamic immunotherapy. Researchers leverage this mechanism to reprogram TAMs, enhancing anti-tumor immune responses in nanodrug-based treatment platforms.

Synthesis

  • Route1
    • null|null
      100516-55-0
    • ~93%
    • In-stock
      L-Norvaline|CS-D1371
      6600-40-4

    References

    • Williams, Robert M.; Sinclair, Peter J.; Zhai, Dongguan; Chen, Daimo Journal of the American Chemical Society, 1988 , vol. 110, # 5 p. 1547 - 1557
  • Route2
    • null|null
      161633-98-3
    • ~%
    • In-stock
      D-Norvaline|CS-0015963
      2013-12-9
    • In-stock
      L-Norvaline|CS-D1371
      6600-40-4

    References

    • Journal of the American Chemical Society, , vol. 116, # 18 p. 8126 - 8132
  • Route3
    • null|null
      141895-39-8
    • ~92%
    • In-stock
      L-Norvaline|CS-D1371
      6600-40-4

    References

    • Cativiela; Diaz-de-Villegas; Galvez Tetrahedron Asymmetry, 1992 , vol. 3, # 4 p. 567 - 572

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   63.32
  • LogP   0.1984
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   3

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