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Structure of 66121-71-9
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4-Cyano-1-methylpyrazole is a bench-stable heterocycle featuring a nitrile group at the 4-position and a methyl substituent at the 1-position. This combination imparts enhanced electron-withdrawing character and improved solubility in organic solvents, enabling efficient integration into medicinal chemistry campaigns. The molecule serves as a bioisostere for carboxylic acids and amides, facilitating targeted modulation of target affinity and metabolic stability.
4-Cyano-1-methylpyrazole serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to pyrazole-based scaffolds through nucleophilic substitution and transition-metal-catalyzed coupling reactions. Its cyano group enhances electrophilicity for C–C bond formation, while the methylpyrazole core provides metabolic stability and favorable pharmacokinetic properties. The compound exhibits excellent bench stability and ease of purification, facilitating integration into multi-step synthetic sequences for API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: