Beaucage reagent

Name: Beaucage reagent
Brand: ChemScene
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CAS No. 66304-01-6
Cat. No. CS-6141
Molecule weight200.24
Purity≥98%
MDL No.MFCD00132960

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 66304-01-6
Cat. No. CS-6141
Purity ≥98%
MDL No. MFCD00132960
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₄O₃S₂
Molecular Weight 200.24
Synonym(s) None
SMILES O=C(C1=CC=CC=C12)SS2(=O)=O

Description

Beaucage reagent delivers efficient phosphitylation under standard conditions, enabling rapid synthesis of phosphoramidite intermediates. This bench-stable reagent features a reactive phosphorus center paired with a protected nucleoside moiety, ensuring high coupling efficiency and minimal side reactions during oligonucleotide assembly workflows.

Application

Beaucage reagent serves as a reliable phosphitylating agent for the synthesis of oligonucleotides, enabling efficient 3′-O-phosphoramidite formation under mild conditions. Its bench-stable nature and high coupling efficiency facilitate reproducible solid-phase DNA/RNA synthesis, with excellent functional group tolerance and straightforward purification by standard chromatographic methods.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 51.21
LogP 1.2623
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Sulfonate

Building Blocks Skeleton Aromatic heterocycle compounds Other aromatic heterocycles compounds

Chemical Biology Pharmaceutical Development and Drug Discovery Research Nucleic Acid Chemistry Phosphorylating Agents, Phosphorothioating Agents

Chemical Biology Pharmaceutical Development and Drug Discovery Research Nucleic Acid Chemistry Sulfur Transfer Reagents

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Nucleic Acid Chemistry Phosphorylating Agents, Phosphorothioating Agents

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Nucleic Acid Chemistry Sulfur Transfer Reagents

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Beaucage reagent

CAS No. 66304-01-6

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