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Structure of 66370-75-0
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Methyl 2-(2-iodophenyl)acetate is a bench-stable aryl iodide derivative featuring a strategically positioned ester group. This combination enables direct functionalization in cross-coupling reactions, serving as a key intermediate for synthesizing biaryl scaffolds. The para-iodo substitution enhances reactivity in palladium-catalyzed transformations while the ester moiety provides a handle for downstream derivatization.
Methyl 2-(2-iodophenyl)acetate serves as a versatile building block for palladium-catalyzed cross-coupling reactions, enabling efficient C–C bond formation at the ortho-position of the phenyl ring. Its iodide functionality exhibits high reactivity in Suzuki, Stille, and Negishi couplings, while the ester group provides orthogonal handle for further functionalization. The compound demonstrates excellent bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis in medicinal chemistry and process development workflows.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: