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Structure of 6652-16-0
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4-(3-(Trifluoromethyl)phenyl)piperidine hydrochloride features a trifluoromethyl-substituted phenyl ring fused to a piperidine core, delivering enhanced lipophilicity and metabolic stability. This scaffold serves as a key building block in medicinal chemistry for CNS-targeted therapeutics, offering improved membrane permeability and target engagement under standard bench conditions.
4-(3-(Trifluoromethyl)phenyl)piperidine hydrochloride serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive compounds through standard amine functionalization and coupling reactions. Its trifluoromethylated aryl group enhances metabolic stability and membrane permeability, while the piperidine core provides a rigid, basic nitrogen for hydrogen bonding and target engagement. The hydrochloride salt ensures excellent solubility and bench stability, facilitating straightforward handling and purification in multi-step syntheses.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: