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CS-W001157 4
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4-(3-Fluorobenzyloxy)benzaldehyde

  • CAS No. 66742-57-2

  • Cat. No. CS-M0748
  • Purity≥98%
  • MDL No.MFCD02605317

*For research and further manufacturing use only, not for direct human use.

4-(3-Fluorobenzyloxy)benzaldehyde|CS-M0748

Structure of 66742-57-2

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General Information

  • CAS No. 66742-57-2
  • Cat. No. CS-M0748
  • Purity ≥98%
  • MDL No. MFCD02605317
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₁FO₂
  • Molecular Weight 230.24
  • Synonym(s) None
  • SMILES O=CC1=CC=C(C=C1)OCC2=CC(F)=CC=C2

Description

4-(3-Fluorobenzyloxy)benzaldehyde features a fluorinated benzyl ether linkage that enhances metabolic stability and modulates lipophilicity. The aldehyde functionality enables direct use in coupling reactions, while the ortho-fluorine substituent influences electronic properties for targeted molecular design. This compound serves as a key building block in medicinal chemistry and materials synthesis.

Application

4-(3-Fluorobenzyloxy)benzaldehyde serves as a versatile building block in medicinal chemistry, enabling the construction of complex aromatic scaffolds through standard coupling and functional group manipulation. Its ortho-fluorinated benzyl ether moiety enhances metabolic stability and modulates lipophilicity, while the aldehyde functionality facilitates imine formation, reductive amination, and oxime derivatization. The compound exhibits excellent bench stability and is compatible with common purification methods, making it well-suited for high-throughput synthesis and lead optimization workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   3.2172
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   4

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