N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine

Name: N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine
Brand: ChemScene
Availability: InStock
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CAS No. 67219-55-0
Cat. No. CS-W011422
Purity≥95%
MDL No.MFCD00010114

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine|CS-W011422

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Description

N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine is a protected cytidine derivative designed for solid-phase oligonucleotide synthesis. The 5'-O-dimethoxytrityl group enables efficient chain elongation and purification, while the N4-benzoyl protection ensures stability during coupling steps. This derivative integrates cleanly into DNA sequences under standard conditions, offering high fidelity in automated synthesis workflows.

Application

N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine serves as a key building block in solid-phase oligonucleotide synthesis, enabling efficient and sequence-specific chain elongation. The 5'-O-(4,4'-dimethoxytrityl) group provides robust protection for the 5'-hydroxyl with excellent solubility and ease of monitoring via trityl cation release. The N4-benzoyl group ensures stability during synthesis while allowing straightforward deprotection under standard conditions. This derivative exhibits high functional group tolerance and compatibility with standard coupling protocols, facilitating reliable access to cytidine-containing DNA sequences for research and therapeutic applications.

General Information

CAS No. 67219-55-0
Cat. No. CS-W011422
Purity ≥95%
MDL No. MFCD00010114
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃₇H₃₅N₃O₇
Molecular Weight 633.69
Synonym(s) 5'-O-DMT-N4-Bz-dC
SMILES O=C(N=C(NC(C1=CC=CC=C1)=O)C=C2)N2[C@H]3C[C@H](O)[C@@H](COC(C4=CC=C(OC)C=C4)(C5=CC=C(OC)C=C5)C6=CC=CC=C6)O3

Computational Chemistry Data

TPSA 121.14
LogP 5.1699
H_Acceptors 9
H_Donors 2
Rotatable_Bonds 11

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS08
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H340-H350
Precautionary Statements : P280-P405-P501

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Other Classifications

Life Science Nucleosides & Nucleotides DNA Phosphoramidite Monomer

Chemical Biology Pharmaceutical Development and Drug Discovery Research Nucleic Acid Chemistry Protected Nucleosides

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Nucleic Acid Chemistry Protected Nucleosides

Chemical Biology Nucleic Acid Chemistry Nucleoside Phosphoramidites

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleoside Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleosides

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Oligonucleotides, DNA, and RNA

Key Words

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N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine

CAS No. 67219-55-0

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