tert-Butyl (2-hydroxy-1-phenylethyl)carbamate

Name: tert-Butyl (2-hydroxy-1-phenylethyl)carbamate
Brand: ChemScene
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CAS No. 67341-01-9
Cat. No. CS-W022966
Purity≥97%
MDL No.MFCD01883039

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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tert-Butyl (2-hydroxy-1-phenylethyl)carbamate|CS-W022966

Structure of 67341-01-9

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Description

tert-Butyl (2-hydroxy-1-phenylethyl)carbamate delivers a protected hydroxyl group flanked by a chiral benzylic center, enabling stereocontrolled synthesis in complex molecule assembly. The carbamate moiety ensures stable protection under standard conditions while permitting selective deprotection via mild acidolysis. This scaffold integrates seamlessly into peptide and natural product frameworks, offering enhanced solubility and handling advantages in synthetic workflows.

Application

tert-Butyl (2-hydroxy-1-phenylethyl)carbamate serves as a stable, bench-friendly chiral auxiliary for asymmetric synthesis, enabling stereoselective transformations via its protected hydroxyl and amine functionalities. The carbamate group facilitates efficient deprotection under mild acidic conditions, while the pendant phenyl and hydroxyl moieties support orthogonal functionalization in complex molecule assembly. Its robust stability and predictable reactivity make it a reliable building block for pharmaceutical intermediates and natural product synthesis.

General Information

CAS No. 67341-01-9
Cat. No. CS-W022966
Purity ≥97%
MDL No. MFCD01883039
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₁₉NO₃
Molecular Weight 237.30
Synonym(s) N-Boc-DL-2-phenylglycinol
SMILES O=C(OC(C)(C)C)NC(C1=CC=CC=C1)CO

Computational Chemistry Data

TPSA 58.56
LogP 2.2447
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 3

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Alcohol

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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tert-Butyl (2-hydroxy-1-phenylethyl)carbamate

CAS No. 67341-01-9

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