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CS-W001157 4
Total: USD 88.00

1H-Indazole-4-carboxylic acid

  • CAS No. 677306-38-6

  • Cat. No. CS-D0831
  • Purity≥98%
  • MDL No.MFCD03840644

*For research and further manufacturing use only, not for direct human use.

1H-Indazole-4-carboxylic acid|CS-D0831

Structure of 677306-38-6

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General Information

  • CAS No. 677306-38-6
  • Cat. No. CS-D0831
  • Purity ≥98%
  • MDL No. MFCD03840644
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆N₂O₂
  • Molecular Weight 162.15
  • Synonym(s) 4-Indazolecarboxylic acid
  • SMILES O=C(C1=CC=CC2=C1C=NN2)O

Description

1H-Indazole-4-carboxylic acid features a rigid, electron-deficient heteroaromatic core that integrates seamlessly into bioactive scaffolds. The carboxylic acid group enables direct conjugation or derivatization under standard coupling conditions. This compound serves as a key building block for pharmaceutical intermediates and functional materials, offering enhanced metabolic stability and predictable binding interactions in medicinal chemistry applications.

Application

1H-Indazole-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocycles. Its carboxylic acid functionality facilitates direct amidation, esterification, and coupling reactions under standard conditions. The indazole core provides structural rigidity and favorable pharmacophoric properties, supporting its use in scaffold-hopping and lead optimization campaigns. Bench-stable and readily purified by recrystallization, it functions effectively in multi-step syntheses requiring functional group tolerance and predictable reactivity.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P264-P270-P280-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   65.98
  • LogP   1.2611
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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