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Structure of 67808-66-6
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Methyl 5-formylthiophene-3-carboxylate features a thiophene core bearing both formyl and ester functionalities, enabling direct incorporation into heterocyclic scaffolds. The electron-deficient thiophene ring facilitates cross-coupling reactions, while the formyl group supports nucleophilic additions and condensation chemistries. This bifunctional reagent streamlines access to complex bioactive molecules under standard conditions.
Methyl 5-formylthiophene-3-carboxylate serves as a versatile heterocyclic building block featuring orthogonal aldehyde and ester functionalities. The formyl group enables direct functionalization via nucleophilic additions, oxime formation, or reductive amination, while the ester supports hydrolysis, reduction, or coupling reactions. Its thiophene core provides structural rigidity and electronic modulation, making it suitable for synthesizing bioactive scaffolds in medicinal chemistry and materials science. The compound exhibits good bench stability and facilitates straightforward purification by column chromatography or recrystallization.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: