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Structure of 67963-68-2
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(4-Bromophenoxy)(tert-butyl)dimethylsilane features a brominated phenoxy group tethered to a bulky silyl moiety, enabling stable coupling in cross-coupling reactions. The tert-butyl dimethylsilyl protection enhances solubility and shelf stability while facilitating selective deprotection under mild conditions. This reagent streamlines access to functionalized aryl ethers in synthetic workflows.
(4-Bromophenoxy)(tert-butyl)dimethylsilane serves as a stable, bench-ready silyl ether protecting group for phenolic alcohols. It enables selective deprotection under mild fluoride conditions while tolerating a range of functional groups. The brominated aryl moiety facilitates downstream cross-coupling reactions, making this reagent valuable in the synthesis of complex heterocycles and bioactive scaffolds via Pd-catalyzed transformations.
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GHS Pictogram :
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GHS No : GHS02,GHS07
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Signal Word : Danger
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UN#: 1993
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Class : 3
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Packing Group : Ⅱ
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Hazard Statements : H225-H315-H319-H335
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Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P405-P501
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Lot numbers can be found on the outside label of a product: