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Structure of 67967-11-7
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1,7-Naphthyridin-8(7H)-one features a fused bicyclic core with nitrogen atoms at strategic positions, enabling strong hydrogen bonding and enhanced solubility in polar solvents. This scaffold integrates readily into medicinal chemistry libraries due to its planar geometry and ability to engage in directional intermolecular interactions.
1,7-Naphthyridin-8(7H)-one serves as a versatile heterocyclic scaffold in medicinal chemistry, enabling efficient access to nitrogen-containing biaryls and fused ring systems. Its amphoteric nature facilitates metal-catalyzed cross-coupling reactions and functionalization at C3 and C4 positions. The compound exhibits good bench stability and compatibility with common protecting group strategies, making it a practical building block for lead optimization campaigns involving kinase inhibitors and DNA-targeting agents.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: