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Structure of 685827-70-7
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1-(Pyridin-2-yl)piperidine-4-carboxylic acid features a rigid pyridine ring linked to a piperidine scaffold, delivering enhanced metabolic stability and favorable pharmacokinetic properties. This structural motif integrates a hydrogen-bonding carboxylic acid group with a basic nitrogen center, enabling strong target engagement in kinase inhibition and GPCR modulation. The molecule exhibits improved solubility and cell permeability compared to analogous aliphatic analogs.
1-(Pyridin-2-yl)piperidine-4-carboxylic acid serves as a versatile scaffold in medicinal chemistry, enabling the construction of bioactive heterocycles through standard amide coupling and cyclization protocols. The pyridine moiety enhances solubility and provides a handle for metal coordination, while the piperidine core offers conformational flexibility and hydrogen-bonding capacity. Bench-stable and readily purified by recrystallization or chromatography, it functions effectively in both solution-phase synthesis and solid-phase combinatorial libraries.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H226-H315-H319
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Precautionary Statements : P210-P233-P240-P241-P242-P243-P264-P280-P362+P364-P370+P378-P501
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Lot numbers can be found on the outside label of a product: