H-Leu-Gly-OH

Name: H-Leu-Gly-OH
Brand: ChemScene
Availability: InStock
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CAS No. 686-50-0
Cat. No. CS-W016791
Purity≥98%
MDL No.MFCD00065940

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 686-50-0

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General Information

CAS No. 686-50-0
Cat. No. CS-W016791
Purity ≥98%
MDL No. MFCD00065940
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₁₆N₂O₃
Molecular Weight 188.22
Synonym(s) L-Leucylglycine; Leu-Gly
SMILES O=C(CNC([C@H](CC(C)C)N)=O)O

Description

H-Leu-Gly-OH is a dipeptide intermediate featuring a leucine residue linked to glycine via a stable amide bond. This sequence combines the hydrophobic character of leucine with the conformational flexibility of glycine, enabling efficient incorporation into peptide synthesis workflows. The N-terminal protected form ensures compatibility with standard coupling conditions and facilitates sequential elongation in solid-phase or solution-phase strategies.

Application

H-Leu-Gly-OH serves as a reliable dipeptide building block for peptide synthesis, offering excellent bench stability and straightforward purification. Its well-defined side-chain functionality enables efficient coupling reactions with minimal epimerization, making it suitable for both manual and automated synthesis workflows. The sequence provides a robust scaffold for C-terminal modifications and is widely used in the construction of bioactive peptides and peptidomimetics.

Synthesis

Route1
- 26117-20-4
- In-stock
  
  6000-44-8
- ~82%
- In-stock
  
  686-50-0
References
- Lagrille, Olivier; Taillades, Jacques; Boiteau, Laurent; Commeyras, Auguste European Journal of Organic Chemistry, 2002 , # 6 p. 1026 - 1032
Route2
- 51220-76-9
- ~0%
- In-stock
  
  686-50-0
- 5815-67-8
References
- Coursindel, Thibault; Restouin, Audrey; Dewynter, Georges; Martinez, Jean; Collette, Yves; Parrot, Isabelle Bioorganic Chemistry, 2010 , vol. 38, # 5 p. 210 - 217
Route3
- 56-40-6
- In-stock
  
  3190-70-3
- ~87%
- In-stock
  
  686-50-0
- In-stock
  
  462-60-2
References
- Kircher, K.; Berndt, H.; Zahn, H. Liebigs Annalen der Chemie, 1980 , # 2 p. 275 - 284

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 92.42
LogP -0.4394
H_Acceptors 3
H_Donors 3
Rotatable_Bonds 5

Other Classifications

Bioactive Molecules Peptides

Life Science Amino Acids and their Derivatives Glycine and derivatives

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Biochemistry Biochemicals and Reagents Peptides Dipeptides and Tripeptides

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H-Leu-Gly-OH

CAS No. 686-50-0

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