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CS-W001157 4
Total: USD 88.00

Hydroxyproline

  • CAS No. 6912-67-0

  • Cat. No. CS-0454925
  • Molecule weight131.13
  • Purity≥98%
  • MDL No.MFCD00066718

*For research and further manufacturing use only, not for direct human use.

Hydroxyproline|CS-0454925

Structure of 6912-67-0

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General Information

  • CAS No. 6912-67-0
  • Cat. No. CS-0454925
  • Purity ≥98%
  • MDL No. MFCD00066718
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₉NO₃
  • Molecular Weight 131.13
  • Synonym(s) DL-Hydroxyproline
  • SMILES O=C(C1NCC(C1)O)O

Description

4-Hydroxypyrrolidine-2-carboxylic acid features a rigid pyrrolidine ring with a hydroxyl group at the 4-position and a carboxylic acid at C2, enabling precise stereochemical control in peptide synthesis. This scaffold integrates readily into bioactive molecules, offering enhanced solubility and hydrogen-bonding capacity for medicinal chemistry applications.

Application

4-Hydroxypyrrolidine-2-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and peptidomimetics. Its hydroxyl and carboxylic acid functionalities offer orthogonal handles for derivatization, while the pyrrolidine core provides conformational rigidity. The compound exhibits good bench stability and facilitates efficient purification, making it well-suited for iterative synthetic campaigns and API intermediate development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   69.56
  • LogP   -1.2062
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   1

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