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CS-W001157 4
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2,6-Dimethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

  • CAS No. 693774-10-6

  • Cat. No. CS-0036233
  • Purity≥97%
  • MDL No.None
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    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

2,6-Dimethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine|CS-0036233

Structure of 693774-10-6

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Description

This pyridine boronate features a sterically hindered 2,6-dimethyl substitution pattern that enhances stability and minimizes undesired side reactions. The tetramethylborolane moiety enables efficient coupling under mild conditions, making it ideal for Suzuki-Miyaura cross-coupling applications in complex molecule synthesis.

Application

2,6-Dimethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine serves as a stable, bench-ready boronate building block for Suzuki-Miyaura cross-coupling reactions. Its ortho-methyl groups enhance regioselectivity and electronic modulation in heterocyclic coupling, while the sterically protected boronate moiety ensures excellent shelf stability and compatibility with diverse functional groups. Ideal for constructing complex pyridine-based scaffolds in medicinal chemistry and materials science applications.

General Information

  • CAS No. 693774-10-6
  • Cat. No. CS-0036233
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₀BNO₂
  • Molecular Weight 233.11
  • Synonym(s) 3-Hydroxy-2,3-diMethylbutan-2-yl hydrogen (2,6-diMethylpyridin-3-yl)boronate
  • SMILES CC1=NC(=C(C=C1)B2OC(C)(C)C(C)(C)O2)C

Computational Chemistry Data

  • TPSA   31.35
  • LogP   1.99764
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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