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CS-W001157 4
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Ethyl 2-hydrazinylacetate hydrochloride

  • CAS No. 6945-92-2

  • Cat. No. CS-W002085
  • Purity≥95%
  • MDL No.MFCD00012923

*For research and further manufacturing use only, not for direct human use.

Ethyl 2-hydrazinylacetate hydrochloride|CS-W002085

Structure of 6945-92-2

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General Information

  • CAS No. 6945-92-2
  • Cat. No. CS-W002085
  • Purity ≥95%
  • MDL No. MFCD00012923
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₁₁ClN₂O₂
  • Molecular Weight 154.60
  • Synonym(s) Ethyl hydrazinoacetate hydrochloride
  • SMILES CCOC(=O)CNN.Cl

Description

Ethyl hydrazinoacetate hydrochloride has been used in the preparation of three novel copper(II) complexes as condensation derivatives of 2-pyridinecarboxaldehyde, 2-acetylpyridine and 2-quinolinecarboxaldehyde.

Application

Ethyl 2-hydrazinylacetate hydrochloride serves as a versatile building block for heterocyclic synthesis, enabling efficient access to pyrazole and triazole scaffolds under mild conditions. Its hydrazinyl group exhibits high reactivity toward carbonyl compounds and activated alkenes, facilitating one-pot cyclizations with excellent functional group tolerance. The hydrochloride salt enhances bench stability and simplifies handling, while the ethyl ester moiety supports downstream derivatization via hydrolysis or nucleophilic substitution. This compound is particularly valuable in medicinal chemistry workflows requiring rapid scaffold diversification.

Synthesis

  • Route1

    References

    • Chemische Berichte, , vol. 31, p. 167

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   64.35
  • LogP   -0.5654
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   3

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