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CS-W001157 4
Total: USD 88.00

3-Methyl-1H-pyrazole-5-carboxylic acid

  • CAS No. 696-22-0

  • Cat. No. CS-0166799
  • Purity≥97%
  • MDL No.None
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-Methyl-1H-pyrazole-5-carboxylic acid|CS-0166799

Structure of 696-22-0

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Description

3-Methyl-1H-pyrazole-5-carboxylic acid features a pyrazole core functionalized with a carboxylic acid at the 5-position and a methyl group at the 3-position, delivering enhanced solubility and metabolic stability. This scaffold integrates readily into bioactive molecule design, particularly in kinase inhibitors and heterocyclic drug candidates.

Application

3-Methyl-1H-pyrazole-5-carboxylic acid serves as a versatile building block for heterocyclic synthesis, enabling efficient access to bioactive scaffolds via standard coupling and cyclization protocols. Its carboxylic acid functionality facilitates direct amidation, esterification, and derivatization under routine conditions, while the methyl group enhances metabolic stability. The molecule exhibits good bench stability and is compatible with common protecting group strategies, making it well-suited for medicinal chemistry campaigns and process-scale applications.

General Information

  • CAS No. 696-22-0
  • Cat. No. CS-0166799
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₆N₂O₂
  • Molecular Weight 126.11
  • Synonym(s) None
  • SMILES O=C(C1=CC(C)=NN1)O

Computational Chemistry Data

  • TPSA   65.98
  • LogP   0.41632
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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