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CS-W001157 4
Total: USD 88.00

4-bromophenyl isopropyl ether

  • CAS No. 6967-88-0

  • Cat. No. CS-0207507
  • Molecule weight215.09
  • Purity≥97%
  • MDL No.MFCD00089972

*For research and further manufacturing use only, not for direct human use.

4-bromophenyl isopropyl ether|CS-0207507

Structure of 6967-88-0

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General Information

  • CAS No. 6967-88-0
  • Cat. No. CS-0207507
  • Purity ≥97%
  • MDL No. MFCD00089972
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁BrO
  • Molecular Weight 215.09
  • Synonym(s) 1-Bromo-4-isopropoxybenzene
  • SMILES CC(C)OC1=CC=C(C=C1)Br

Description

4-Bromophenyl isopropyl ether features a brominated aromatic ring linked via an ether bond to a sterically hindered isopropyl group. This combination imparts enhanced stability and solubility in organic media, enabling straightforward incorporation into synthetic sequences requiring halogenated aryl intermediates.

Application

4-Bromophenyl isopropyl ether serves as a versatile aryl halide building block in cross-coupling reactions, enabling efficient C–C bond formation via palladium-catalyzed protocols. Its bench-stable nature and compatibility with diverse functional groups facilitate reliable synthesis of substituted biaryls and complex pharmaceutical intermediates. The isopropyl ether moiety enhances solubility and stability while maintaining predictable reactivity under standard coupling conditions.

Synthesis

  • Route1
    • null|null
      75-30-9
    • null|null
      106-41-2
    • ~93%
    • In-stock
      4-bromophenyl isopropyl ether|CS-0207507
      6967-88-0

    References

    • Andreini, Matteo; Gabellieri, Emanuele; Guba, Wolfgang; Marconi, Guido; Narquizian, Robert; Power, Eoin; Travagli, Massimiliano; Woltering, Thomas; Wostl, Wolfgang Patent: US2009/209529 A1, 2009 ; Location in patent: Page/Page column 21 ;
  • Route2
    • null|null
      106-41-2
    • null|null
      75-26-3
    • ~97%
    • In-stock
      4-bromophenyl isopropyl ether|CS-0207507
      6967-88-0

    References

    • Keenan, Martine; Abbott, Michael J.; Alexander, Paul W.; Armstrong, Tanya; Best, Wayne M.; Berven, Bradley; Botero, Adriana; Chaplin, Jason H.; Charman, Susan A.; Chatelain, Eric; Von Geldern, Thomas W.; Kerfoot, Maria; Khong, Andrea; Nguyen, Tien; McManus, Joshua D.; Morizzi, Julia; Ryan, Eileen; Scandale, Ivan; Thompson, R. Andrew; Wang, Sen Z.; White, Karen L. Journal of Medicinal Chemistry, 2012 , vol. 55, # 9 p. 4189 - 4204
  • Route3

    References

    • Yakabe, Shigetaka; Hirano, Masao; Morimoto, Takashi Organic Preparations and Procedures International, 1998 , vol. 30, # 2 p. 218 - 222

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   3.2363
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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