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CS-W001157 4
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2-(6-Hydroxy-1-benzofuran-3-yl)acetic acid

  • CAS No. 69716-04-7

  • Cat. No. CS-M1953
  • Molecule weight192.17
  • Purity≥96%
  • MDL No.MFCD05273635

*For research and further manufacturing use only, not for direct human use.

2-(6-Hydroxy-1-benzofuran-3-yl)acetic acid|CS-M1953

Structure of 69716-04-7

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General Information

  • CAS No. 69716-04-7
  • Cat. No. CS-M1953
  • Purity ≥96%
  • MDL No. MFCD05273635
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₈O₄
  • Molecular Weight 192.17
  • Synonym(s) 6-Hydroxy-3-benzofuranacetic acid
  • SMILES O=C(O)CC1=COC2=CC(O)=CC=C12

Description

This benzofuran-based carboxylic acid integrates a hydroxyl group at the 6-position, enhancing solubility and enabling derivatization. The acetic acid side chain provides a reactive handle for conjugation, while the aromatic core imparts stability. Suitable for synthetic intermediates in medicinal chemistry and bioconjugation applications.

Application

2-(6-Hydroxy-1-benzofuran-3-yl)acetic acid serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its structure combines a benzofuran core with a pendant carboxylic acid, enabling facile derivatization via esterification, amidation, or coupling reactions. The hydroxyl group offers additional sites for protection or functionalization, while the molecule exhibits good bench stability and compatibility with standard purification techniques.

Synthesis

  • Route1

    References

    • Heterocycles, , vol. 41, # 4 p. 647 - 650
  • Route2
    • null|null
      108-46-3
    • ~%
    • In-stock
      2-(6-Hydroxy-1-benzofuran-3-yl)acetic acid|CS-M1953
      69716-04-7

    References

    • WO2012/11125 A1, ; WO 2012/011125 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   70.67
  • LogP   1.7655
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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