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CS-W001157 4
Total: USD 88.00

4-Fluoro-1-methyl-1H-pyrazole

  • CAS No. 69843-14-7

  • Cat. No. CS-0454976
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

4-Fluoro-1-methyl-1H-pyrazole|CS-0454976

Structure of 69843-14-7

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Description

4-Fluoro-1-methyl-1H-pyrazole is a bench-stable, electron-deficient heterocycle featuring a fluorine atom at the 4-position and a methyl group at nitrogen. This combination imparts enhanced reactivity in cross-coupling processes and improved metabolic stability in bioactive molecule design. The pyrazole scaffold serves as a rigid, polar pharmacophore that integrates efficiently into medicinal chemistry libraries.

Application

4-Fluoro-1-methyl-1H-pyrazole serves as a versatile heterocyclic building block in medicinal chemistry, enabling the construction of bioactive scaffolds through established coupling and functionalization protocols. Its fluorinated pyrazole core offers enhanced metabolic stability and modulated electronic properties, while the methyl group provides a handle for further derivatization. The compound exhibits good bench stability and compatibility with standard synthetic workflows, facilitating efficient incorporation into complex molecular architectures.

General Information

  • CAS No. 69843-14-7
  • Cat. No. CS-0454976
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅FN₂
  • Molecular Weight 100.09
  • Synonym(s) 4-fluoro-1-methylpyrazole
  • SMILES CN1C=C(C=N1)F

Computational Chemistry Data

  • TPSA   17.82
  • LogP   0.5592
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group :
Hazard Statements : H225-H315-H319
Precautionary Statements : P210-P233-P240-P241-P242-P243-P264-P280-P302+P352-P362+P364-P370+P378-P501

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