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CS-W001157 4
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4-Fluoro-1-methyl-1H-pyrazole

  • CAS No. 69843-14-7

  • Cat. No. CS-0454976
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Fluoro-1-methyl-1H-pyrazole|CS-0454976

Structure of 69843-14-7

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General Information

  • CAS No. 69843-14-7
  • Cat. No. CS-0454976
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅FN₂
  • Molecular Weight 100.09
  • Synonym(s) 4-fluoro-1-methylpyrazole
  • SMILES CN1C=C(C=N1)F

Description

4-Fluoro-1-methyl-1H-pyrazole is a bench-stable, electron-deficient heterocycle featuring a fluorine atom at the 4-position and a methyl group at nitrogen. This combination imparts enhanced reactivity in cross-coupling processes and improved metabolic stability in bioactive molecule design. The pyrazole scaffold serves as a rigid, polar pharmacophore that integrates efficiently into medicinal chemistry libraries.

Application

4-Fluoro-1-methyl-1H-pyrazole serves as a versatile heterocyclic building block in medicinal chemistry, enabling the construction of bioactive scaffolds through established coupling and functionalization protocols. Its fluorinated pyrazole core offers enhanced metabolic stability and modulated electronic properties, while the methyl group provides a handle for further derivatization. The compound exhibits good bench stability and compatibility with standard synthetic workflows, facilitating efficient incorporation into complex molecular architectures.

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H225-H315-H319
Precautionary Statements : P210-P233-P240-P241-P242-P243-P264-P280-P302+P352-P362+P364-P370+P378-P501

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Computational Chemistry Data

  • TPSA   17.82
  • LogP   0.5592
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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