1-(2-Chloro-4-fluorophenyl)ethanone

Name: 1-(2-Chloro-4-fluorophenyl)ethanone
Brand: ChemScene
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CAS No. 700-35-6
Cat. No. CS-W008455
Purity≥96%
MDL No.MFCD00042202

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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1-(2-Chloro-4-fluorophenyl)ethanone|CS-W008455

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General Information

CAS No. 700-35-6
Cat. No. CS-W008455
Purity ≥96%
MDL No. MFCD00042202
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₆ClFO
Molecular Weight 172.58
Synonym(s) 2-chloro-4-fluoroacetophenone
SMILES CC(C1=CC=C(F)C=C1Cl)=O

Description

1-(2-Chloro-4-fluorophenyl)ethanone features a fluorinated aromatic ring paired with a chlorinated ortho-position, delivering enhanced electron-withdrawing character. This ketone integrates readily into pharmaceutical intermediates and synthetic scaffolds requiring halogenated aryl functionality. Its bench-stable nature supports reliable use in multistep transformations under standard conditions.

Application

1-(2-Chloro-4-fluorophenyl)ethanone serves as a versatile aryl ketone building block in medicinal chemistry and process development. Its fluorinated aromatic core provides enhanced metabolic stability and modulates electronic properties, while the acetyl group enables facile transformations such as α-functionalization, reduction to secondary alcohols, or incorporation into chalcone scaffolds. Bench-stable and amenable to standard purification techniques, it functions reliably in multistep syntheses requiring halogen-directed functionalization or coupling reactions.

Synthesis

Route1
- 625-98-9
- 75-36-5
- ~%
- In-stock
  
  700-35-6
References
- Journal of the Chemical Society, , p. 2784 - 2787
Route2
- 625-98-9
- 108-24-7
- ~%
- In-stock
  
  700-35-6
References
- Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , p. 119 - 125

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 17.07
LogP 2.6817
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Ketone

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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1-(2-Chloro-4-fluorophenyl)ethanone

CAS No. 700-35-6

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