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CS-W001157 4
Total: USD 88.00

1-Bromo-2-phenoxybenzene

  • CAS No. 7025-06-1

  • Cat. No. CS-W005331
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Bromo-2-phenoxybenzene|CS-W005331

Structure of 7025-06-1

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General Information

  • CAS No. 7025-06-1
  • Cat. No. CS-W005331
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₉BrO
  • Molecular Weight 249.10
  • Synonym(s) 2-Bromophenylphenyl ether
  • SMILES BrC1=C(OC2=CC=CC=C2)C=CC=C1

Description

1-Bromo-2-phenoxybenzene features a phenoxy substituent adjacent to a bromine atom on a benzene ring, enabling direct coupling in cross-coupling reactions. This electron-deficient aryl halide integrates readily into complex molecular architectures under standard conditions.

Application

1-Bromo-2-phenoxybenzene serves as a versatile aryl halide building block for palladium-catalyzed cross-coupling reactions, including Suzuki-Miyaura and Stille couplings. Its stability under standard reaction conditions and tolerance to common functional groups enable reliable construction of biaryl architectures. The phenoxy substituent enhances solubility and provides orthogonal reactivity in multi-step syntheses. This compound functions effectively in the assembly of complex heterocyclic scaffolds and advanced intermediates relevant to pharmaceutical and materials chemistry.

Synthesis

  • Route1
    • 2-Phenoxyaniline Nimesulide Impurity|CS-0229591
      2688-84-8
    • ~45%
    • In-stock
      1-Bromo-2-phenoxybenzene|CS-W005331
      7025-06-1

    References

    • ASTRAZENECA AB Patent: US2008/15237 A1, 2008 ; Location in patent: Page/Page column 34 ; US 20080015237 A1
  • Route2
    • null|null
      95-56-7
    • In-stock
      Phenylboronic acid|CS-W001090
      98-80-6
    • ~46%
    • In-stock
      1-Bromo-2-phenoxybenzene|CS-W005331
      7025-06-1

    References

    • STERIX LIMITED Patent: WO2009/66072 A2, 2009 ; Location in patent: Page/Page column 99 ; WO 2009/066072 A2
  • Route3
    • null|null
      108-86-1
    • null|null
      95-56-7
    • ~62%
    • In-stock
      1-Bromo-2-phenoxybenzene|CS-W005331
      7025-06-1

    References

    • Kumar, Sangit; Kumar, Amit; Bhakuni, Bhagat Singh; Prasad, Ch. Durga; Kumar, Shailesh Tetrahedron, 2013 , vol. 69, # 26 p. 5383 - 5392

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   4.2414
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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