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CS-W001157 4
Total: USD 88.00

3-Chloro-4-fluorophenylacetic acid

  • CAS No. 705-79-3

  • Cat. No. CS-W016774
  • Molecule weight188.58
  • Purity≥98%
  • MDL No.MFCD01631555

*For research and further manufacturing use only, not for direct human use.

3-Chloro-4-fluorophenylacetic acid|CS-W016774

Structure of 705-79-3

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General Information

  • CAS No. 705-79-3
  • Cat. No. CS-W016774
  • Purity ≥98%
  • MDL No. MFCD01631555
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆ClFO₂
  • Molecular Weight 188.58
  • Synonym(s) (3-Chloro-4-fluorophenyl)acetic acid
  • SMILES C1=C(C=C(C(=C1)F)Cl)CC(=O)O

Description

3-Chloro-4-fluorophenylacetic acid features a strategically positioned chloro and fluoro substituent on the phenyl ring, enhancing electronic effects for downstream coupling reactions. This bench-stable derivative integrates readily into pharmaceutical intermediates and bioactive molecule scaffolds, offering improved solubility and reactivity under standard conditions.

Application

3-Chloro-4-fluorophenylacetic acid serves as a versatile building block for pharmaceutical intermediates, enabling efficient incorporation of fluorinated aromatic motifs into bioactive molecules. Its functional group tolerance supports diverse transformations, including amide coupling and nucleophilic substitution, while the bench-stable carboxylic acid facilitates straightforward purification and handling in multi-step syntheses.

Synthesis

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    • In-stock
      3-Chloro-4-fluorophenylacetic acid|CS-W016774
      705-79-3

    References

    • Journal of Organic Chemistry, , vol. 26, p. 2353 - 2355
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    • ~%
    • In-stock
      3-Chloro-4-fluorophenylacetic acid|CS-W016774
      705-79-3

    References

    • Journal of Organic Chemistry, , vol. 26, p. 2353 - 2355
  • Route3

    References

    • Journal of Organic Chemistry, , vol. 26, p. 2353 - 2355

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.1062
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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