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CS-W001157 4
Total: USD 88.00

(3,5-Difluoro-4-methoxyphenyl)methanol

  • CAS No. 706786-41-6

  • Cat. No. CS-0096370
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(3,5-Difluoro-4-methoxyphenyl)methanol|CS-0096370

Structure of 706786-41-6

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General Information

  • CAS No. 706786-41-6
  • Cat. No. CS-0096370
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈F₂O₂
  • Molecular Weight 174.14
  • Synonym(s) 3,5-Difluoro-4-methoxybenzyl alcohol
  • SMILES OCC1=CC(F)=C(OC)C(F)=C1

Description

This bench-stable phenolic alcohol features a 3,5-difluoro-4-methoxyphenyl scaffold, delivering enhanced electronic and steric control. The methoxy group stabilizes electron density, while the ortho-fluorines enable selective functionalization in synthetic sequences. Ideal for coupling reactions and medicinal chemistry applications requiring halogen-directed derivatization.

Application

(3,5-Difluoro-4-methoxyphenyl)methanol serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated aromatic scaffolds. Its benzylic alcohol functionality facilitates straightforward derivatization—such as oxidation to carboxylic acids or conversion to esters and ethers—while the ortho-fluorine substituents enhance metabolic stability and modulate electronic properties. The methoxy group provides a handle for further functionalization and contributes favorable lipophilicity. Bench-stable and compatible with standard reaction conditions, it functions effectively in coupling, cyclization, and heterocycle construction workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.46
  • LogP   1.4657
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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