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CS-W001157 4
Total: USD 88.00

5-(Bromomethyl)-1,3-difluoro-2-methoxybenzene

  • CAS No. 706786-42-7

  • Cat. No. CS-0199499
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

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    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-(Bromomethyl)-1,3-difluoro-2-methoxybenzene|CS-0199499

Structure of 706786-42-7

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Description

5-(Bromomethyl)-1,3-difluoro-2-methoxybenzene features a reactive bromomethyl group flanked by electron-withdrawing difluoro substituents and a methoxy handle, enabling selective functionalization in synthetic routes. The molecule combines enhanced stability with high electrophilicity, facilitating efficient coupling reactions under mild conditions. This aryl bromide serves as a valuable intermediate for constructing complex fluorinated scaffolds in medicinal chemistry and materials science.

Application

5-(Bromomethyl)-1,3-difluoro-2-methoxybenzene serves as a versatile building block for the synthesis of fluorinated aromatic scaffolds. The bromomethyl group enables efficient Suzuki, Stille, and Ullmann coupling reactions, while the ortho-difluoro and methoxy substituents provide enhanced metabolic stability and modulated electronic properties. This compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for iterative medicinal chemistry campaigns and API intermediate development.

General Information

  • CAS No. 706786-42-7
  • Cat. No. CS-0199499
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇BrF₂O
  • Molecular Weight 237.04
  • Synonym(s) 3,5-Difluoro-4-methoxybenzyl bromide
  • SMILES COC1=C(C=C(C=C1F)CBr)F

Computational Chemistry Data

  • TPSA   9.23
  • LogP   2.8683
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group :
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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