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CS-W001157 4
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N-Methyl-N-(piperidin-4-yl)methanesulfonamide

  • CAS No. 70724-74-2

  • Cat. No. CS-W003951
  • Purity≥95%
  • MDL No.MFCD12086666

*For research and further manufacturing use only, not for direct human use.

N-Methyl-N-(piperidin-4-yl)methanesulfonamide|CS-W003951

Structure of 70724-74-2

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General Information

  • CAS No. 70724-74-2
  • Cat. No. CS-W003951
  • Purity ≥95%
  • MDL No. MFCD12086666
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₆N₂O₂S
  • Molecular Weight 192.28
  • Synonym(s) N-Methyl-N-4-piperidinyl-methanesulfonamide
  • SMILES CN(S(=O)(=O)C)C1CCNCC1

Description

N-Methyl-N-(piperidin-4-yl)methanesulfonamide features a piperidine ring bearing a methanesulfonamide group and a methyl substituent, delivering enhanced solubility and metabolic stability. This scaffold integrates readily into medicinal chemistry campaigns targeting kinase inhibition and CNS-penetrant molecules, offering favorable pharmacokinetic properties under standard bench conditions.

Application

N-Methyl-N-(piperidin-4-yl)methanesulfonamide serves as a versatile sulfonamide building block in medicinal chemistry, enabling efficient access to bioactive heterocycles. Its piperidine core offers favorable solubility and metabolic stability, while the methanesulfonyl group provides a robust handle for further functionalization. The compound exhibits bench stability and compatibility with standard coupling and reductive amination protocols, facilitating rapid scaffold diversification in lead optimization campaigns.

Synthesis

  • Route1
    • null|null
      124-63-0
    • In-stock
      1-Boc-4-methylaminopieridine|CS-D0641
      147539-41-1
    • ~%
    • In-stock
      N-Methyl-N-(piperidin-4-yl)methanesulfonamide|CS-W003951
      70724-74-2

    References

    • F. HOFFMANN-LA ROCHE AG Patent: WO2009/47161 A1, 2009 ; Location in patent: Page/Page column 140 ;
  • Route2
    • In-stock
      1-(4-(Methylamino)piperidin-1-yl)ethan-1-one|CS-0108614
      139062-96-7
    • null|null
      124-63-0
    • ~%
    • In-stock
      N-Methyl-N-(piperidin-4-yl)methanesulfonamide|CS-W003951
      70724-74-2

    References

    • Pfizer Inc. Patent: US4289772 A1, 1981 ; US 4289772 A

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.41
  • LogP   -0.3702
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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