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CS-W001157 4
Total: USD 88.00

2-(2-Bromophenyl)propan-2-ol

  • CAS No. 7073-69-0

  • Cat. No. CS-0036294
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(2-Bromophenyl)propan-2-ol|CS-0036294

Structure of 7073-69-0

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General Information

  • CAS No. 7073-69-0
  • Cat. No. CS-0036294
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁BrO
  • Molecular Weight 215.09
  • Synonym(s) Benzenemethanol, 2-bromo-alpha,alpha-dimethyl-
  • SMILES CC(C)(C1=CC=CC=C1Br)O

Description

This bench-stable, moisture-tolerant tertiary alcohol features a sterically hindered carbon center flanked by a brominated phenyl group. It integrates readily into coupling reactions and serves as a key intermediate in the synthesis of functionalized biaryl compounds under standard conditions.

Application

2-(2-Bromophenyl)propan-2-ol serves as a stable, bench-ready building block for the synthesis of biaryl scaffolds and functionalized heterocycles. Its tertiary alcohol functionality enables direct coupling reactions, while the ortho-bromo substituent facilitates palladium-catalyzed cross-coupling transformations. The molecule exhibits excellent functional group tolerance and simplifies purification due to its crystalline nature, making it well-suited for iterative synthetic sequences in medicinal chemistry and process development.

Synthesis

  • Route1
    • In-stock
      Methyl 2-bromobenzoate|CS-W007744
      610-94-6
    • null|null
      75-16-1
    • ~99%
    • In-stock
      2-(2-Bromophenyl)propan-2-ol|CS-0036294
      7073-69-0

    References

    • Player, Mark R.; Dax, Scott L.; Parsons, William H.; Brandt, Michael Richard; Calvo, Raul R.; Patel, Sharmila; Liu, Jian; Cheung, Wing S.; Jetter, Michele C.; Lee, Yu-Kai; Youngman, Mark A.; Pan, Wenxi; Weils, Kenneth M.; Beauchamp, Derek A. Patent: US2007/259936 A1, 2007 ; Location in patent: Page/Page column 171-172 ; US 20070259936 A1
  • Route2
    • In-stock
      Ethyl 2-bromobenzoate|CS-0097784
      6091-64-1
    • null|null
      676-58-4
    • ~69%
    • In-stock
      2-(2-Bromophenyl)propan-2-ol|CS-0036294
      7073-69-0

    References

    • PFIZER JAPAN INC.; HASHIZUME, Yoshinobu; PFIZER INC. Patent: WO2005/92858 A2, 2005 ; Location in patent: Page/Page column 141 ; WO 2005/092858 A2
  • Route3
    • In-stock
      Methyl 2-bromobenzoate|CS-W007744
      610-94-6
    • null|null
      676-58-4
    • ~99%
    • In-stock
      2-(2-Bromophenyl)propan-2-ol|CS-0036294
      7073-69-0

    References

    • ANACOR PHARMACEUTICALS, INC.; CHEN, Daitao; ORR, Matthew; SLIGAR, Jessica; JACOBS, Robert; PLATTNER, Jacob, J. Patent: WO2011/19618 A1, 2011 ; Location in patent: Page/Page column 137-138 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.6765
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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