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Structure of 7073-99-6
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1-Bromo-2-(tert-butyl)benzene features a bromine atom ortho to a bulky tert-butyl group, creating a sterically hindered aryl halide. This substitution pattern enhances stability and directs electrophilic aromatic substitution regioselectively. The compound serves as a key building block in synthesizing functionalized biaryls and pharmaceutical intermediates under palladium-catalyzed coupling conditions.
1-Bromo-2-(tert-butyl)benzene serves as a versatile aryl halide building block for palladium-catalyzed cross-coupling reactions, including Suzuki, Stille, and Negishi couplings. The bulky tert-butyl group provides steric protection and enhances solubility, while the bromine moiety enables reliable functionalization under standard conditions. This compound exhibits excellent bench stability and facilitates efficient synthesis of substituted biaryls and complex aromatic scaffolds relevant to medicinal chemistry and materials science.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: