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Structure of 71759-87-0
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4-Iodo-1-methyl-1H-imidazole is a bench-stable, moisture-tolerant heterocyclic reagent featuring a reactive iodide at the C4 position and a methyl group at nitrogen. This combination enables efficient coupling in palladium-catalyzed cross-coupling reactions, particularly Suzuki-Miyaura and Buchwald-Hartwig transformations. The electron-deficient imidazole ring enhances electrophilicity, facilitating selective functionalization.
4-Iodo-1-methyl-1H-imidazole serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl architectures. Its iodine atom facilitates reliable Suzuki, Stille, and Negishi couplings under standard conditions. The methyl-substituted imidazole core provides enhanced bench stability and improved solubility compared to unsubstituted analogs, simplifying handling and purification in medicinal chemistry workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: