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CS-W001157 4
Total: USD 88.00

Methyl 2-bromo-2-(4-fluorophenyl)acetate

  • CAS No. 71783-54-5

  • Cat. No. CS-0695727
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Methyl 2-bromo-2-(4-fluorophenyl)acetate|CS-0695727

Structure of 71783-54-5

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General Information

  • CAS No. 71783-54-5
  • Cat. No. CS-0695727
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈BrFO₂
  • Molecular Weight 247.06
  • Synonym(s) None
  • SMILES COC(=O)C(Br)C1=CC=C(F)C=C1

Description

Methyl 2-bromo-2-(4-fluorophenyl)acetate is a bench-stable, moisture-tolerant reagent featuring a brominated alpha-carbon adjacent to a fluorinated aryl group. This electrophilic site enables direct functionalization in cross-coupling reactions and facilitates the synthesis of complex fluorinated building blocks for medicinal chemistry applications.

Application

Methyl 2-bromo-2-(4-fluorophenyl)acetate serves as a versatile building block for the synthesis of fluorinated aromatic intermediates. The geminal bromide and ester functionalities enable sequential functionalization, including nucleophilic substitution and transition-metal-catalyzed coupling reactions. Its bench-stable nature and compatibility with standard purification protocols make it well-suited for use in medicinal chemistry and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   2.4347
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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