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Structure of 717843-48-6
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3-Bromo-6-methylpicolinonitrile features a bromine substituent and a methyl group positioned ortho to the nitrile moiety on a picolinonitrile scaffold. This electron-deficient heterocycle enables direct functionalization in cross-coupling reactions, offering enhanced reactivity for constructing complex nitrogen-containing architectures under mild conditions.
3-Bromo-6-methylpicolinonitrile serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal functionalization profile. The nitrile group facilitates downstream transformations such as amide formation or reduction, while the bromine supports Suzuki, Stille, and Negishi couplings. Bench-stable and readily purified by recrystallization, it functions effectively in the synthesis of heterocyclic scaffolds and bioactive molecules.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: