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CS-W001157 4
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Biotin-C5-NHS Ester

  • CAS No. 72040-63-2

  • Cat. No. CS-0116277
  • Molecule weight454.54
  • Purity≥96%
  • MDL No.MFCD00065502

*For research and further manufacturing use only, not for direct human use.

Biotin-C5-NHS Ester|CS-0116277

Structure of 72040-63-2

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General Information

  • CAS No. 72040-63-2
  • Cat. No. CS-0116277
  • Purity ≥96%
  • MDL No. MFCD00065502
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₀H₃₀N₄O₆S
  • Molecular Weight 454.54
  • Synonym(s) NHS LC biotin
  • SMILES O=C(ON1C(CCC1=O)=O)CCCCCNC(CCCC[C@@H]2SC[C@]([C@]2([H])N3)([H])NC3=O)=O

Description

Intercalating into avidin binding pockets with minimal steric occlusion, Biotinamidohexanoic acid N-hydroxysuccinimide ester (CAS 72040-63-2) enables efficient conjugation in membrane-permeable labeling assays.

Application

Biotinamidohexanoic acid N-hydroxysuccinimide ester (CAS 72040-63-2) enables efficient antibody biotinylation through rapid conjugation with primary amines on lysine residues and terminal amino groups. This reaction is highly specific and stable. Researchers use it to generate high-affinity detection probes for immunoassays, flow cytometry, and protein capture systems.

Synthesis

  • Route1

    References

    • Wang, Tzu-Pin; Chiou, Yi-Jang; Chen, Yi; Wang, Eng-Chi; Hwang, Long-Chih; Chen, Bing-Hung; Chen, Yen-Hsu; Ko, Chun-Han Bioconjugate Chemistry, 2010 , vol. 21, # 9 p. 1642 - 1655
  • Route2
    • null|null
      4443-68-9
    • ~%
    • In-stock
      Biotin-C5-NHS Ester|CS-0116277
      72040-63-2

    References

    • Bioconjugate Chemistry, , vol. 21, # 9 p. 1642 - 1655
  • Route3
    • 2,5-Dioxopyrrolidin-1-yl 5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate|CS-0379935
      85718-04-3
    • ~%
    • In-stock
      Biotin-C5-NHS Ester|CS-0116277
      72040-63-2

    References

    • Bioconjugate Chemistry, , vol. 21, # 9 p. 1642 - 1655

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   133.91
  • LogP   0.996
  • H_Acceptors   7
  • H_Donors   3
  • Rotatable_Bonds   12

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