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CS-W001157 4
Total: USD 88.00

2,4-Dibromobenzene-1-sulfonyl chloride

  • CAS No. 72256-95-2

  • Cat. No. CS-W009416
  • Molecule weight334.41
  • Purity≥96%
  • MDL No.MFCD03093759

*For research and further manufacturing use only, not for direct human use.

2,4-Dibromobenzene-1-sulfonyl chloride|CS-W009416

Structure of 72256-95-2

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General Information

  • CAS No. 72256-95-2
  • Cat. No. CS-W009416
  • Purity ≥96%
  • MDL No. MFCD03093759
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃Br₂ClO₂S
  • Molecular Weight 334.41
  • Synonym(s) 2,4-DIBROMOBENZENESULPHONYL CHLORIDE
  • SMILES O=S(C1=CC=C(Br)C=C1Br)(Cl)=O

Description

Mal-PEG1-Val-Cit-PAB-OH is a cleavable ADC linker intermediate which contains a maleimide, a hydrophilic PEG spacer, a valine-citrulline (Val-Cit) dipeptide, and a para-aminobenzyl (PAB) spacer. Maleimide is a thiol-specific functional group which is used to label cysteine residues in proteins. Val-Cit-PAB linkers are cleaved by cytoplasmic peptidases.

Synthesis

  • Route1

    References

    • Journal of the American Chemical Society, , vol. 62, p. 511,512
  • Route2
    • null|null
      7790-94-5
    • In-stock
      1,3-Dibromobenzene|CS-W008980
      108-36-1
    • ~%
    • In-stock
      2,4-Dibromobenzene-1-sulfonyl chloride|CS-W009416
      72256-95-2
    • null|null
      686349-70-2

    References

    • Doklady Akademii Nauk SSSR, , vol. 112, p. 872,873 Doklady Chemistry, 112-117 <1957> 133, 134

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   34.14
  • LogP   3.1391
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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