Lot numbers can be found on the outside label of a product:
Methyl 2-cyano-2-methylpropanoate
-
CAS No. 72291-30-6
- Cat. No. CS-0028771
- Purity≥98%
- MDL No.MFCD03428328
*For research and further manufacturing use only, not for direct human use.
Structure of 72291-30-6
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 72291-30-6
- Cat. No. CS-0028771
- Purity ≥98%
- MDL No. MFCD03428328
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₆H₉NO₂
- Molecular Weight 127.14
- Synonym(s) 2,2-Dimethyl-2-cyanoacetic acid methyl ester; 2-Cyano-2,2-dimethylacetic acid methyl ester; 2,2-DIMETHYLCYANOACETATE METHYL ESTER
- SMILES CC(C)(C#N)C(OC)=O
Description
Methyl 2-cyano-2-methylpropanoate features a sterically hindered α,α-dimethyl ester group flanked by a nitrile functionality, enabling robust participation in Michael additions and multicomponent couplings. This bench-stable reagent integrates efficiently into synthetic sequences requiring controlled carbon–carbon bond formation under mild conditions.
Application
Methyl 2-cyano-2-methylpropanoate serves as a robust building block in synthetic organic chemistry, enabling efficient access to sterically hindered nitriles and α-amino nitriles via nucleophilic addition reactions. Its tert-butyl-like steric profile enhances stability under basic conditions and facilitates straightforward purification. The molecule functions effectively in Michael additions, Mannich-type reactions, and as a precursor to heterocyclic scaffolds including pyrrolidines and imidazoles.
Synthesis
-
Route1
-
In-stock
105-34-0 -
74-88-4 - ~71%
-
In-stock
72291-30-6
References
-
Nippon Steel Corporation; Nippon Steel Chemical Co., Ltd. Patent: US5866592 A1, 1999 ;
-
-
Route2
-
105-56-6
-
77-78-1
- ~%
-
In-stock
1572-98-1 -
In-stock
72291-30-6
References
-
WO2012/21446 A2, ; Page/Page column 29 ;
-
-
Route3
-
74-87-3
-
In-stock
105-34-0
- ~%
-
In-stock
72291-30-6
References
-
WO2010/112482 A1, ; Page/Page column 27 ;
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H227-H302+H312+H332-H315-H319
|
|
|
Precautionary Statements : P210-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P403-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 50.09
- LogP 0.70918
- H_Acceptors 3
- H_Donors 0
- Rotatable_Bonds 1
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- Methyl 2-cyano-2-methylpropanoate sigmaMethyl 2-cyano-2-methylpropanoate manufacturerMethyl 2-cyano-2-methylpropanoate priceMethyl 2-cyano-2-methylpropanoate structureMethyl 2-cyano-2-methylpropanoate SDSbuy Methyl 2-cyano-2-methylpropanoateMethyl 2-cyano-2-methylpropanoate supplierMethyl 2-cyano-2-methylpropanoate usesMethyl 2-cyano-2-methylpropanoate molecular weightprice of Methyl 2-cyano-2-methylpropanoateMethyl 2-cyano-2-methylpropanoate chemical name formula of Methyl 2-cyano-2-methylpropanoate