4,6-Dichloroquinazoline

Name: 4,6-Dichloroquinazoline
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 7253-22-7
Cat. No. CS-W004034
Purity≥97%
MDL No.MFCD00089492

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

4,6-Dichloroquinazoline is a bench-stable, electron-deficient heterocycle featuring two chlorine substituents at the 4- and 6-positions of the quinazoline core. This configuration enhances reactivity in nucleophilic substitution processes, enabling efficient coupling with diverse amines and thiols to construct functionalized derivatives for medicinal chemistry applications.

Application

4,6-Dichloroquinazoline serves as a versatile building block in medicinal chemistry, enabling straightforward functionalization at C4 and C6 positions via palladium-catalyzed cross-coupling reactions. Its high reactivity and bench stability facilitate efficient synthesis of quinazoline-based kinase inhibitors and other bioactive heterocycles, with excellent functional group tolerance and predictable regioselectivity in standard synthetic workflows.

General Information

CAS No. 7253-22-7
Cat. No. CS-W004034
Purity ≥97%
MDL No. MFCD00089492
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₄Cl₂N₂
Molecular Weight 199.04
Synonym(s) Quinazoline,4,6-dichloro
SMILES ClC1=CC(C(Cl)=NC=N2)=C2C=C1

Computational Chemistry Data

TPSA 25.78
LogP 2.9366
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05,GHS06
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H301-H315-H318-H335
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Quinazoline compounds

Key Words

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4,6-Dichloroquinazoline

CAS No. 7253-22-7

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